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"The new BPEs can coexist in the Cisco uBR7225VXR chassis with earlier Cisco uBR7200 Series MC16U and MC28U line cards should you choose to reuse these line cards in the Cisco uBR7225VXR.

Note: The new Cisco uBR7225VXR E-28U and E-16U BPEs (part numbers UBR-E-28U and UBR-E-16U) are compatible with the uBR7225VXR only and are not compatible with the Cisco uBR7246VXR. This compatibility function is enabled through both mechanical keying methodology and software locks to prevent insertion of these cards into any other chassis" (Cisco Data Sheet).